A Different Perspective
on Human Aging

Aging is more than the passage of time. It reflects the lifelong accumulation of environmental, lifestyle and sensory influences—the Exposome.

A&S combines Exposome science, Sensory Science and Bio-Responsive Ingredients to explore how neurobiological pathways may be regulated to reduce aging-related impacts, strengthen biological resilience and support healthier aging.

Illuminated brain connected to blue and gold sensory pathways

How the Exposome
Shapes Human Aging

How cumulative biological burden advances through molecular and organ-system change—and how ADI captures the aging trajectory.

Older woman enjoying a sunlit outdoor café
Older woman walking through the city with a cup of coffee
Everyday ExposuresAir · UV · Diet · Stress · Sensory Inputs

EMII

Exposome-Mediated Impact Index

Lifelong exposures accumulate as biological burden.

  1. Higher
    EMII
  2. Greater
    Biological Burden
  3. Accelerated
    Metastatic Aging

As EMII rises, biological burden increases and the aging cascade accelerates.

Metastatic Aging

Scientist studying molecular biology using a microscope

Molecular-Level Aging

DNA damage · Telomere shortening · Epigenetic changes · Proteostasis loss

Healthcare professional consulting with an older man

Organ-System-Level Aging

Neural · Metabolic · Immune · Skin · Physiological decline

Aging-related changes propagate across biological scales.

Three illustrated brains connected through successive stages of aging 30s50s70s

Human Aging

The lived outcome of cumulative biological change.

Researcher reviewing aging trajectories on a computer display

ADI

Aging Dynamic Index

An integrated view of molecular changes, physiological function and human aging over time.

Human Aging

Four Interconnected Domains of Human Aging

A systems view of how metabolic, physical, neural and signaling changes interact over time.

Metabolic & Energy Shifts

Changes in mitochondrial function and glucose regulation can reduce cellular energy availability and metabolic flexibility.

Mitochondrial function · Glucose regulation

Older woman checking an upper-arm glucose sensor beside fresh food and a phone

Body Composition & Physical Function

Loss of muscle mass, shifts in fat distribution and declining mobility can reduce strength and physical resilience.

Muscle mass · Fat distribution · Mobility

Older man doing a strengthening exercise with a physical therapist
Interconnected

Neurodegeneration & Cognitive Decline

Changes in neuronal health and brain volume can affect memory, attention and cognitive performance.

Neuronal health · Brain volume changes

Older man discussing brain-scan results with a healthcare professional

Homeostatic Signaling Networks

Disrupted cell-to-cell communication and declining stem-cell function can weaken repair, adaptation and biological balance.

Cell communication · Stem-cell function

Illustrated cells connected by blue and gold signaling pathways
ADI · Aging Dynamic Index

Aging Dynamics Index (ADI)

Developed by the A&S research team, ADI is a research-based computational index. By integrating multiple aging-related parameters, it is designed to observe the current degree of aging and track how its progression and rate change over time, providing a systematic framework for aging research.

EBIIExposome Biological Impact Index

The cumulative biological impact of environmental, lifestyle and sensory exposures.

Older woman walking along a lively café-lined street

IPIntrinsic Susceptibility

Individual biological characteristics that influence vulnerability to aging-related change.

Chromosome and genetic information displayed on a laboratory monitor

Genetics · Epigenetics · Baseline physiology

ADI=EBII×IPAR

Higher EBII or IP increases ADI, while stronger AR moderates it.

ARAging Resilience

The biological capacity to maintain balance, adapt, repair and recover.

Hand grip-strength assessment using a digital dynamometer
Repair · Recovery · Adaptation · Functional reserve

How to Interpret ADI

ADI is interpreted as a continuum rather than a diagnosis. Its value reflects the relative degree and pace of aging-related change observed within the A&S research framework.

Lower / SlowerHigher / Faster
Older man walking comfortably outdoors

Lower ADI

  • Slower Aging Trajectory
  • Stronger resilience
  • More stable biological function
Older woman exercising with a dumbbell and a healthcare professional

Intermediate ADI

  • Adaptive Aging Trajectory
  • Emerging aging-related change
  • Biological compensation remains active
Older man walking indoors with a cane

Higher ADI

  • Accelerated Aging Trajectory
  • Greater biological burden
  • Reduced resilience and faster functional change

ADI Across Time

Direction Matters. Rate Matters.

A single ADI value reflects a point in time. Repeated observations reveal whether aging-related change is stable, slowing or accelerating.

Changes in biological impact and resilience can shift the ADI trajectory over time.
Illustrative ADI trajectories from baseline to Year 5: accelerating rises, stable remains nearly level, and slowing falls. The vertical axis is ADI level and the horizontal axis is time.

Scroll horizontally to view the full chart.

Healthcare professional reviewing mobility, balance, grip strength, daily function and well-being on a tablet

Current Degree

A snapshot of aging-related status

Researcher comparing trajectories over repeated observations on a monitor

Direction

How ADI changes over repeated observations

Three views of an older woman walking outside

Rate

How quickly the trajectory changes